Overexpression of acid ceramidase (ASAH1) protects retinal cells (ARPE19) from oxidative stress[S]
Over 11 million people in the United States alone have some form of age-related macular degeneration (AMD).Oxidative stress, cell death, and the degeneration of retinal pigment epithelial (RPE) cells contribute to AMD pathology.Recent evidence suggests that ceramide (Cer), a cellular sphingolipid mediator that acts Cholesterol Synthesis as a second